Revealing hidden complexities of genomic rearrangements generated with Cas9

Editorial Commentary: Genomic Epidemiology: Revealing Hidden Reservoirs for Klebsiella pneumoniae

Classically defined infectious disease epidemiology is being upended by the replacement of low-resolution phenotypic and molecular technologies with highresolution whole-genome shotgun sequencing of pathogens. The evolution of molecular epidemiology has been under way for 10 years, but the speed of the transition has recently quickened. Previously unrecognized pathogen reservoirs and modes of t...

Hidden Complexities in Assessment of Glycemic Outcomes

OBJECTIVE To evaluate facility rankings in achieving <7% A1C levels based on the complexity of glycemic treatment regimens using threshold and continuous measures. RESEARCH DESIGN AND METHODS We conducted a retrospective administrative data analysis of Veterans Health Administration Medical Centers in 2003-2004. Eligible patients were identified using National Committee for Quality Assurance ...

Hidden Complexities of PLLs Are Revealed

In order to achieve the timing goals needed in their ASIC designs, many engineers decide to include phase-locked loops (PLLs). Phaselocked loops have a number of desirable properties that include the ability to multiply clock frequencies, correct clock duty cycles, and cancel out clock distribution delays. These properties allow designers to use inexpensive, low-frequency crystals as their off-...

Genomic Rearrangements and Evolution

Revealing Hidden Genuine Tripartite Nonlocality

Nonlocal correlations arising from measurements on tripartite entangled states can be classified into two groups, one genuinely 3−way nonlocal and other local with respect to some bipartition. Still, whether a genuinely tripartite entangled quantum state can exhibit genuine 3−way nonlocality, remains a challenging problem so far as measurement context is concerned. Here we introduce a novel app...